Mito-xenophagic killing of bacteria is coordinated by a metabolic switch in dendritic cells

Mito-xenophagic killing of bacteria is coordinated by a metabolic switch in dendritic cells

Abstract Chlamydiae are bacterial pathogens that grow in vacuolar inclusions. Dendritic cells (DCs) disintegrate these compartments, thereby eliminating the microbes, through auto/xenophagy, which also promotes chlamydial antigen presentation via MHC I. Here, we show that TNF-α controls this pathway...

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Bibliographic Details
Main Authors: Nadine Radomski, Danny Kägebein, Elisabeth Liebler-Tenorio, Axel Karger, Elke Rufer, Birke Andrea Tews, Stefanie Nagel, Rebekka Einenkel, Anne Müller, Annica Rebbig, Michael R. Knittler
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04142-5

Internet

https://doi.org/10.1038/s41598-017-04142-5

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