Notch1-ADAM8 positive feed-back loop regulates the degradation of chondrogenic extracellular matrix and osteoarthritis progression

Notch1-ADAM8 positive feed-back loop regulates the degradation of chondrogenic extracellular matrix and osteoarthritis progression

Abstract Background Osteoarthritis (OA) is one of the most prevalent joint disease, and there are still no effective therapeutic agents or clinical methods for the cure of this disease to date. The degradation of cartilage extracellular matrix (ECM) is a major cause of OA. Method IL-1β was used to i...

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Bibliographic Details
Main Authors: Biao Duan, Yan Liu, He Hu, Fu-Guo Shi, Ya-Long Liu, Hao Xue, Xin-Yu Yun, Ming-Yu Yan, Xi-Rui Han, An-Fu Chen, Yong Wang, Zhe-Hai Li
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Cell Communication and Signaling
Subjects:
Notch1
ADAM8
ECM
MMP-9
Osteoarthritis
Online Access:http://link.springer.com/article/10.1186/s12964-019-0443-2

Internet

http://link.springer.com/article/10.1186/s12964-019-0443-2

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