5-methoxytryptophan: an arsenal against vascular injury and inflammation

5-methoxytryptophan: an arsenal against vascular injury and inflammation

Abstract 5-methoxytryptophan (5-MTP) is an endothelial factor with anti-inflammatory properties. It is synthesized from L-tryptophan via two enzymatic steps: tryptophan hydroxylase-1 (TPH-1) and hydroxyindole O-methyltransferase. Lipopolysaccharide (LPS) and pro-inflammatory cytokines suppress endot...

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Bibliographic Details
Main Authors: Kenneth K. Wu, Cheng-Chin Kuo, Shaw-Fang Yet, Chii-Ming Lee, Jun-Yang Liou
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Biomedical Science
Subjects:
5-methoxytryptophan
Tryptophan hydroxylase-1
Hydroxyindole O-methyltransferase
Intimal hyperplasia
Endothelial barrier function
Smooth muscle cell migration and proliferation
Online Access:http://link.springer.com/article/10.1186/s12929-020-00671-w

Internet

http://link.springer.com/article/10.1186/s12929-020-00671-w

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