Synthesis and Evaluation of [<sup>18</sup>F]FEtLos and [<sup>18</sup>F]AMBF<sub>3</sub>Los as Novel <sup>18</sup>F-Labelled Losartan Derivatives for Molecular Imaging of Angiotensin II Type 1 Receptors

Synthesis and Evaluation of [<sup>18</sup>F]FEtLos and [<sup>18</sup>F]AMBF<sub>3</sub>Los as Novel <sup>18</sup>F-Labelled Losartan Derivatives for Molecular Imaging of Angiotensin II Type 1 Receptors

Losartan is widely used in clinics to treat cardiovascular related diseases by selectively blocking the angiotensin II type 1 receptors (AT<sub>1</sub>Rs), which regulate the renin-angiotensin system (RAS). Therefore, monitoring the physiological and pathological biodistribution of AT<...

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Bibliographic Details
Main Authors: Martha Sahylí Ortega Pijeira, Paulo Sérgio Gonçalves Nunes, Sofia Nascimento dos Santos, Zhengxing Zhang, Arian Pérez Nario, Efrain Araujo Perini, Walter Miguel Turato, Zalua Rodríguez Riera, Roger Chammas, Philip H. Elsinga, Kuo-Shyan Lin, Ivone Carvalho, Emerson Soares Bernardes
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
fluoroethyl-losartan
[<sup>18</sup>F]FEtLos
ammoniomethyltrifluoroborate-losartan
[<sup>18</sup>F]AMBF<sub>3</sub>Los
angiotensin II type 1 receptors
[<sup>18</sup>F]Fluoroethylation
Online Access:https://www.mdpi.com/1420-3049/25/8/1872

Internet

https://www.mdpi.com/1420-3049/25/8/1872

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