Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity.

Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity.

The development of an effective vaccine against tuberculosis (Tb) represents one of the major medical challenges of this century. Mycobacterium bovis Bacille Calmette-Guerin (BCG), the only vaccine available at present, is mostly effective at preventing disseminated Tb in children, but shows variabl...

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Bibliographic Details
Main Authors: Luciana Berod, Philipp Stüve, Filipa Varela, Jochen Behrends, Maxine Swallow, Friederike Kruse, Freyja Krull, Peyman Ghorbani, Christian T Mayer, Christoph Hölscher, Tim Sparwasser
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4106855?pdf=render

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http://europepmc.org/articles/PMC4106855?pdf=render

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