Synthesis and Structure-Activity Relationship Analysis of 5-HT7 Receptor Antagonists: Piperazin-1-yl Substituted Unfused Heterobiaryls

Synthesis and Structure-Activity Relationship Analysis of 5-HT7 Receptor Antagonists: Piperazin-1-yl Substituted Unfused Heterobiaryls

A series of piperazin-1-yl substituted unfused heterobiaryls was synthesized as ligands of the 5-HT7 receptors. The goal of this project was to elucidate the structural features that affect the 5-HT7 binding affinity of this class of compounds represented by the model ligand 4-(3-furyl)-2-(4-methylp...

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Bibliographic Details
Main Authors: Lucjan Strekowski, Jarosław Sączewski, Elizabeth A. Raux, Nilmi T. Fernando, Jeff Klenc, Shirish Paranjpe, Aldona Raszkiewicz, Ava L. Blake, Adam J. Ehalt, Samuel Barnes, Timothy C. Baranowski, Shannon M. Sullivan, Grzegorz Satała, Andrzej J. Bojarski
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:Molecules
Subjects:
5-HT7 receptor ligands
5-HT
serotonin
synthesis
structure-affinity relationships (SAR)
N-methylpiperazine
3-furyl
Online Access:http://www.mdpi.com/1420-3049/21/4/433

Internet

http://www.mdpi.com/1420-3049/21/4/433

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