Distinguishing the differences in β-glycosylceramidase folds, dynamics, and actions informs therapeutic uses

Distinguishing the differences in β-glycosylceramidase folds, dynamics, and actions informs therapeutic uses

Glycosyl hydrolases (GHs) are carbohydrate-active enzymes that hydrolyze a specific β-glycosidic bond in glycoconjugate substrates; β-glucosidases degrade glucosylceramide, a ubiquitous glycosphingolipid. GHs are grouped into structurally similar families that themselves can be grouped into clans. G...

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Bibliographic Details
Main Authors: Fredj Ben Bdira, Marta Artola, Herman S. Overkleeft, Marcellus Ubbink, Johannes M.F.G. Aerts
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Journal of Lipid Research
Subjects:
cerebrosides
cholesterol
glycolipids
Gaucher disease
enzymology
crystal
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520341523

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http://www.sciencedirect.com/science/article/pii/S0022227520341523

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