Inhibiting Monoacylglycerol Lipase Suppresses RANKL-Induced Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss

Inhibiting Monoacylglycerol Lipase Suppresses RANKL-Induced Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss

Osteoporosis is a common chronic metabolic bone disease characterized by reduced trabecular bone and increased bone fragility. Monoacylglycerol lipase (MAGL) is a lipolytic enzyme to catalyze the hydrolysis of monoglycerides and specifically degrades the 2-arachidonoyl glycerol (2-AG). Previous stud...

Full description

Bibliographic Details
Main Authors: Hui Liu, Chuankun Zhou, Dahu Qi, Yutong Gao, Meipeng Zhu, Tenghui Tao, Xuying Sun, Jun Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
osteoporosis
monoacylglycerol lipase
JZL184
osteoclasts
receptor activator of nuclear factor (NF)-κB ligand (RANKL)
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.640867/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.640867/full

Similar Items