Do optimal prognostic thresholds in continuous physiological variables really exist? Analysis of origin of apparent thresholds, with systematic review for peak oxygen consumption, ejection fraction and BNP.

Do optimal prognostic thresholds in continuous physiological variables really exist? Analysis of origin of apparent thresholds, with systematic review for peak oxygen consumption, ejection fraction and BNP.

BACKGROUND:Clinicians are sometimes advised to make decisions using thresholds in measured variables, derived from prognostic studies. OBJECTIVES:We studied why there are conflicting apparently-optimal prognostic thresholds, for example in exercise peak oxygen uptake (pVO2), ejection fraction (EF),...

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Bibliographic Details
Main Authors: Alberto Giannoni, Resham Baruah, Tora Leong, Michaela B Rehman, Luigi Emilio Pastormerlo, Frank E Harrell, Andrew J S Coats, Darrel P Francis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3903471?pdf=render

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http://europepmc.org/articles/PMC3903471?pdf=render

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