A Heat-Killed Cryptococcus Mutant Strain Induces Host Protection against Multiple Invasive Mycoses in a Murine Vaccine Model

A Heat-Killed Cryptococcus Mutant Strain Induces Host Protection against Multiple Invasive Mycoses in a Murine Vaccine Model

Invasive fungal infections kill more than 1.5 million people each year, with limited treatment options. There is no vaccine available in clinical use to prevent and control fungal infections. Our recent studies showed that a mutant of the F-box protein Fbp1, a subunit of the SCF(Fbp1) E3 ligase in C...

Full description

Bibliographic Details
Main Authors: Yina Wang, Keyi Wang, Jorge A. Masso-Silva, Amariliz Rivera, Chaoyang Xue
Format: Article
Language:English
Published: American Society for Microbiology 2019-11-01
Series:mBio
Subjects:
cryptococcus neoformans
fbp1
fungal vaccine
invasive fungal infection
mice
Online Access:https://doi.org/10.1128/mBio.02145-19

Internet

https://doi.org/10.1128/mBio.02145-19

Similar Items