CIITA-Driven MHC Class II Expressing Tumor Cells as Antigen Presenting Cell Performers: Toward the Construction of an Optimal Anti-tumor Vaccine

CIITA-Driven MHC Class II Expressing Tumor Cells as Antigen Presenting Cell Performers: Toward the Construction of an Optimal Anti-tumor Vaccine

Construction of an optimal vaccine against tumors relies on the availability of appropriate tumor-specific antigens capable to stimulate CD4+ T helper cells (TH) and CD8+ cytolytic T cells (CTL). CTL are considered the major effectors of the anti-tumor adaptive immune response as they recognize anti...

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Bibliographic Details
Main Authors: Roberto S. Accolla, Elise Ramia, Alessandra Tedeschi, Greta Forlani
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
MHC-II
CIITA
CD4+ TH cells
APC
tumor vaccines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01806/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01806/full

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