Human adenovirus-specific γ/δ and CD8+ T cells generated by T-cell receptor transfection to treat adenovirus infection after allogeneic stem cell transplantation.

Human adenovirus-specific γ/δ and CD8+ T cells generated by T-cell receptor transfection to treat adenovirus infection after allogeneic stem cell transplantation.

Human adenovirus infection is life threatening after allogeneic haematopoietic stem cell transplantation (HSCT). Immunotherapy with donor-derived adenovirus-specific T cells is promising; however, 20% of all donors lack adenovirus-specific T cells. To overcome this, we transfected α/β T cells with m...

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Bibliographic Details
Main Authors: Jan Dörrie, Christian Krug, Christian Hofmann, Ina Müller, Verena Wellner, Ilka Knippertz, Stephan Schierer, Simone Thomas, Elke Zipperer, Dieter Printz, Gerhard Fritsch, Gerold Schuler, Niels Schaft, Rene Geyeregger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4188623?pdf=render

Internet

http://europepmc.org/articles/PMC4188623?pdf=render

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