Sepsis Triggers a Late Expansion of Functionally Impaired Tissue-Vascular Inflammatory Monocytes During Clinical Recovery

Sepsis Triggers a Late Expansion of Functionally Impaired Tissue-Vascular Inflammatory Monocytes During Clinical Recovery

Sepsis is characterized by a systemic inflammation that can cause an immune dysfunction, for which the underlying mechanisms are unclear. We investigated the impact of cecal ligature and puncture (CLP)-mediated polymicrobial sepsis on monocyte (Mo) mobilization and functions. Our results show that C...

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Bibliographic Details
Main Authors: Camille Baudesson de Chanville, Benjamin Glenn Chousterman, Pauline Hamon, Marie Laviron, Noelline Guillou, Pierre Louis Loyher, Aida Meghraoui-Kheddar, Sandrine Barthelemy, Philippe Deterre, Alexandre Boissonnas, Christophe Combadière
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
monocytes
sepsis
lung
secondary infection
phagocytosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00675/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00675/full

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