A study of the structural properties of sites modified by the O-linked 6-N-acetylglucosamine transferase.

Protein O-GlcNAcylation (O-GlcNAc) is an essential post-translational modification (PTM) in higher eukaryotes. The O-linked β-N-acetylglucosamine transferase (OGT), targets specific Serines and Threonines (S/T) in intracellular proteins. However, unlike phosphorylation, fewer than 25% of known O-Glc...

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Bibliographic Details
Main Authors: Thiago Britto-Borges, Geoffrey J Barton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5590929?pdf=render