The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target?

Thyrotropin releasing hormone (TRH: Glp-His-Pro-NH2) is a peptide mainly produced by brain neurons. In mammals, hypophysiotropic TRH neurons of the paraventricular nucleus of the hypothalamus integrate metabolic information and drive the secretion of thyrotropin from the anterior pituitary, and thus...

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Bibliographic Details
Main Authors: Jean-Louis Charli, Adair Rodríguez-Rodríguez, Karina Hernández-Ortega, Antonieta Cote-Vélez, Rosa María Uribe, Lorraine Jaimes-Hoy, Patricia Joseph-Bravo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00640/full