Sumoylation Inhibits the Growth Suppressive Properties of Ikaros.
The Ikaros transcription factor is a tumor suppressor that is also important for lymphocyte development. How post-translational modifications influence Ikaros function remains partially understood. We show that Ikaros undergoes sumoylation in developing T cells that correspond to mono-, bi- or poly-...
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doaj-9c9ee37e3a5f469f8a7adf1a80ad15872020-11-25T01:01:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01116e015776710.1371/journal.pone.0157767Sumoylation Inhibits the Growth Suppressive Properties of Ikaros.Apostol ApostolovIsma Litim-MecheriAttila OraveczMarie GoeppPeggy KirstetterPatricia MarchalAntoine IttelLaurent MauvieuxSusan ChanPhilippe KastnerThe Ikaros transcription factor is a tumor suppressor that is also important for lymphocyte development. How post-translational modifications influence Ikaros function remains partially understood. We show that Ikaros undergoes sumoylation in developing T cells that correspond to mono-, bi- or poly-sumoylation by SUMO1 and/or SUMO2/3 on three lysine residues (K58, K240 and K425). Sumoylation occurs in the nucleus and requires DNA binding by Ikaros. Sumoylated Ikaros is less effective than unsumoylated forms at inhibiting the expansion of murine leukemic cells, and Ikaros sumoylation is abundant in human B-cell acute lymphoblastic leukemic cells, but not in healthy peripheral blood leukocytes. Our results suggest that sumoylation may be important in modulating the tumor suppressor function of Ikaros.http://europepmc.org/articles/PMC4912065?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Apostol Apostolov Isma Litim-Mecheri Attila Oravecz Marie Goepp Peggy Kirstetter Patricia Marchal Antoine Ittel Laurent Mauvieux Susan Chan Philippe Kastner |
spellingShingle |
Apostol Apostolov Isma Litim-Mecheri Attila Oravecz Marie Goepp Peggy Kirstetter Patricia Marchal Antoine Ittel Laurent Mauvieux Susan Chan Philippe Kastner Sumoylation Inhibits the Growth Suppressive Properties of Ikaros. PLoS ONE |
author_facet |
Apostol Apostolov Isma Litim-Mecheri Attila Oravecz Marie Goepp Peggy Kirstetter Patricia Marchal Antoine Ittel Laurent Mauvieux Susan Chan Philippe Kastner |
author_sort |
Apostol Apostolov |
title |
Sumoylation Inhibits the Growth Suppressive Properties of Ikaros. |
title_short |
Sumoylation Inhibits the Growth Suppressive Properties of Ikaros. |
title_full |
Sumoylation Inhibits the Growth Suppressive Properties of Ikaros. |
title_fullStr |
Sumoylation Inhibits the Growth Suppressive Properties of Ikaros. |
title_full_unstemmed |
Sumoylation Inhibits the Growth Suppressive Properties of Ikaros. |
title_sort |
sumoylation inhibits the growth suppressive properties of ikaros. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
The Ikaros transcription factor is a tumor suppressor that is also important for lymphocyte development. How post-translational modifications influence Ikaros function remains partially understood. We show that Ikaros undergoes sumoylation in developing T cells that correspond to mono-, bi- or poly-sumoylation by SUMO1 and/or SUMO2/3 on three lysine residues (K58, K240 and K425). Sumoylation occurs in the nucleus and requires DNA binding by Ikaros. Sumoylated Ikaros is less effective than unsumoylated forms at inhibiting the expansion of murine leukemic cells, and Ikaros sumoylation is abundant in human B-cell acute lymphoblastic leukemic cells, but not in healthy peripheral blood leukocytes. Our results suggest that sumoylation may be important in modulating the tumor suppressor function of Ikaros. |
url |
http://europepmc.org/articles/PMC4912065?pdf=render |
work_keys_str_mv |
AT apostolapostolov sumoylationinhibitsthegrowthsuppressivepropertiesofikaros AT ismalitimmecheri sumoylationinhibitsthegrowthsuppressivepropertiesofikaros AT attilaoravecz sumoylationinhibitsthegrowthsuppressivepropertiesofikaros AT mariegoepp sumoylationinhibitsthegrowthsuppressivepropertiesofikaros AT peggykirstetter sumoylationinhibitsthegrowthsuppressivepropertiesofikaros AT patriciamarchal sumoylationinhibitsthegrowthsuppressivepropertiesofikaros AT antoineittel sumoylationinhibitsthegrowthsuppressivepropertiesofikaros AT laurentmauvieux sumoylationinhibitsthegrowthsuppressivepropertiesofikaros AT susanchan sumoylationinhibitsthegrowthsuppressivepropertiesofikaros AT philippekastner sumoylationinhibitsthegrowthsuppressivepropertiesofikaros |
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