Sumoylation Inhibits the Growth Suppressive Properties of Ikaros.
The Ikaros transcription factor is a tumor suppressor that is also important for lymphocyte development. How post-translational modifications influence Ikaros function remains partially understood. We show that Ikaros undergoes sumoylation in developing T cells that correspond to mono-, bi- or poly-...
Main Authors: | Apostol Apostolov, Isma Litim-Mecheri, Attila Oravecz, Marie Goepp, Peggy Kirstetter, Patricia Marchal, Antoine Ittel, Laurent Mauvieux, Susan Chan, Philippe Kastner |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4912065?pdf=render |
Similar Items
-
Correction: Sumoylation Inhibits the Growth Suppressive Properties of Ikaros.
by: PLOS ONE Staff
Published: (2016-01-01) -
Ikaros cooperates with Notch activation and antagonizes TGFβ signaling to promote pDC development.
by: Jérôme Mastio, et al.
Published: (2018-07-01) -
Studying the posttranslational modifications of transcription factor Ikaros and their role in its function
by: Apostolov, Apostol
Published: (2012) -
Studying the posttranslational modifications of transcription factor Ikaros and their role in its function
by: Apostolov, Apostol
Published: (2012) -
Ikaros antagonizes DNA binding by STAT5 in pre-B cells.
by: Beate Heizmann, et al.
Published: (2020-01-01)