Inhibition of Eukaryotic Translation Initiation Factor 5A (eIF5A) Hypusination Suppress p53 Translation and Alters the Association of eIF5A to the Ribosomes

The eukaryotic translation initiation factor 5A (eIF5A) is an essential protein for the viability of the cells whose proposed function is to prevent the stalling of the ribosomes during translation elongation. eIF5A activity requires a unique and functionally essential post-translational modificatio...

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Bibliographic Details
Main Authors: Marianna Martella, Caterina Catalanotto, Claudio Talora, Anna La Teana, Paola Londei, Dario Benelli
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
GC7
p53
Online Access:https://www.mdpi.com/1422-0067/21/13/4583