Generation of Potent Anti-Vascular Endothelial Growth Factor Neutralizing Antibodies from Mouse Phage Display Library for Cancer Therapy

Generation of Potent Anti-Vascular Endothelial Growth Factor Neutralizing Antibodies from Mouse Phage Display Library for Cancer Therapy

Vascular endothelial growth factor (VEGF) is an important stimulator for angiogenesis in solid tumors. Blocking VEGF activity is an effective therapeutic strategy to inhibit tumor growth and metastasis. Avastin, a humanized monoclonal antibody recognizes VEGF, has been approved by the US Food and Dr...

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Bibliographic Details
Main Authors: Yan-Da Lai, Yen-Yu Wu, Yi-Jiue Tsai, Yi-San Tsai, Yu-Ying Lin, Szu-Liang Lai, Chao-Yang Huang, Ying-Yung Lok, Chih-Yung Hu, Jiann-Shiun Lai
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:International Journal of Molecular Sciences
Subjects:
phage display
single chain Fv antibody fragment (scFv)
Fab antibody fragment
angiogenesis
vascular endothelial growth factor (VEGF)
Online Access:http://www.mdpi.com/1422-0067/17/2/214

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http://www.mdpi.com/1422-0067/17/2/214

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