Absence of RIP140 reveals a pathway regulating glut4-dependent glucose uptake in oxidative skeletal muscle through UCP1-mediated activation of AMPK.

Absence of RIP140 reveals a pathway regulating glut4-dependent glucose uptake in oxidative skeletal muscle through UCP1-mediated activation of AMPK.

Skeletal muscle constitutes the major site of glucose uptake leading to increased removal of glucose from the circulation in response to insulin. Type 2 diabetes and obesity are often associated with insulin resistance that can be counteracted by exercise or the use of drugs increasing the relative...

Full description

Bibliographic Details
Main Authors: Asmaà Fritah, Jennifer H Steel, Nadeene Parker, Evanthia Nikolopoulou, Mark Christian, David Carling, Malcolm G Parker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3289711?pdf=render

Internet

http://europepmc.org/articles/PMC3289711?pdf=render

Similar Items