The Ratio of GrzB<sup>+</sup> − FoxP3<sup>+</sup> over CD3<sup>+</sup> T Cells as a Potential Predictor of Response to Nivolumab in Patients with Metastatic Melanoma

The Ratio of GrzB<sup>+</sup> − FoxP3<sup>+</sup> over CD3<sup>+</sup> T Cells as a Potential Predictor of Response to Nivolumab in Patients with Metastatic Melanoma

The understanding of the molecular pathways involved in the dynamic modulation of the tumor microenvironment (TME) has led to the development of innovative treatments for advanced melanoma, including immune checkpoint blockade therapies. These approaches have revolutionized the treatment of melanoma...

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Bibliographic Details
Main Authors: Giosuè Scognamiglio, Mariaelena Capone, Francesco Sabbatino, Annabella Di Mauro, Monica Cantile, Margherita Cerrone, Gabriele Madonna, Antonio Maria Grimaldi, Domenico Mallardo, Marco Palla, Sabrina Sarno, Anna Maria Anniciello, Maurizio Di Bonito, Paolo Antonio Ascierto, Gerardo Botti
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
melanoma
immunotherapy
tumor microenvironment
multiplex immunostaining
immunoscore
Online Access:https://www.mdpi.com/2072-6694/13/10/2325

Internet

https://www.mdpi.com/2072-6694/13/10/2325

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