SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation

The Ras family of GTPases are important in cell signaling and frequently mutated in human tumors. Understanding their regulation is thus important for studying biology and human diseases. Here, we report that a novel posttranslational mechanism, reversible lysine fatty acylation, regulates R-Ras2, a...

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Bibliographic Details
Main Authors: Xiaoyu Zhang, Nicole A Spiegelman, Ornella D Nelson, Hui Jing, Hening Lin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-04-01
Series:eLife
Subjects:
Ras
Online Access:https://elifesciences.org/articles/25158