Essential roles of insulin and IGF-1 receptors during embryonic lineage development

Essential roles of insulin and IGF-1 receptors during embryonic lineage development

The insulin and insulin-like growth factor-1 (IGF-1) receptors are important for the growth and development of embryonic tissues. To directly define their roles in the maintenance of pluripotency and differentiation of stem cells, we knocked out both receptors in induced pluripotent stem cells (iPSC...

Full description

Bibliographic Details
Main Authors: Erin R. Okawa, Manoj K. Gupta, Sevim Kahraman, Praneeth Goli, Masaji Sakaguchi, Jiang Hu, Kaiti Duan, Brittany Slipp, Jochen K. Lennerz, Rohit N. Kulkarni
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Molecular Metabolism
Subjects:
Insulin/IGF-1 receptors
Pluripotency
Lineage development
Signaling
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000041

Internet

http://www.sciencedirect.com/science/article/pii/S2212877821000041

Similar Items