Synthesis and Biological Evaluation of Coumarin-Linked 4-Anilinomethyl-1,2,3-Triazoles as Potent Inhibitors of Carbonic Anhydrases IX and XIII Involved in Tumorigenesis

Synthesis and Biological Evaluation of Coumarin-Linked 4-Anilinomethyl-1,2,3-Triazoles as Potent Inhibitors of Carbonic Anhydrases IX and XIII Involved in Tumorigenesis

A series of coumarin-linked 4-anilinomethyl-1,2,3-triazoles (<b>6a</b>–<b>t</b>) was synthesized via a molecular hybridization approach, through carbon C-6 of the coumarin moiety. The synthesized compounds were evaluated for their inhibition of carbonic anhydrase (CA) isoform...

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Bibliographic Details
Main Authors: Pavitra S. Thacker, Prerna L. Tiwari, Andrea Angeli, Danaboina Srikanth, Baijayantimala Swain, Mohammed Arifuddin, Claudiu T. Supuran
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Metabolites
Subjects:
carbonic anhydrases
coumarin
hCA IX
hCA XIII
1,2,3-triazole
Online Access:https://www.mdpi.com/2218-1989/11/4/225

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https://www.mdpi.com/2218-1989/11/4/225

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