Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro

Cellular cargo transported along actin filaments is faced with a directional choice at an intersection. Here the authors show that myosin Va-bound cargo prefers to go straight through the intersection, and propose a model to explain this by a tug-of-war between motors on the lipid cargo that engage...

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Bibliographic Details
Main Authors: Andrew T. Lombardo, Shane R. Nelson, M. Yusuf Ali, Guy G. Kennedy, Kathleen M. Trybus, Sam Walcott, David M. Warshaw
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15692