Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro

Cellular cargo transported along actin filaments is faced with a directional choice at an intersection. Here the authors show that myosin Va-bound cargo prefers to go straight through the intersection, and propose a model to explain this by a tug-of-war between motors on the lipid cargo that engage...

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Main Authors: Andrew T. Lombardo, Shane R. Nelson, M. Yusuf Ali, Guy G. Kennedy, Kathleen M. Trybus, Sam Walcott, David M. Warshaw
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15692
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spelling doaj-9cbbb6d752f74a68bb343e25f12b6f662021-05-11T07:32:34ZengNature Publishing GroupNature Communications2041-17232017-06-01811910.1038/ncomms15692Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitroAndrew T. Lombardo0Shane R. Nelson1M. Yusuf Ali2Guy G. Kennedy3Kathleen M. Trybus4Sam Walcott5David M. Warshaw6Department of Molecular Physiology and Biophysics, University of VermontDepartment of Molecular Physiology and Biophysics, University of VermontDepartment of Molecular Physiology and Biophysics, University of VermontDepartment of Molecular Physiology and Biophysics, University of VermontDepartment of Molecular Physiology and Biophysics, University of VermontDepartment of Mathematics, University of CaliforniaDepartment of Molecular Physiology and Biophysics, University of VermontCellular cargo transported along actin filaments is faced with a directional choice at an intersection. Here the authors show that myosin Va-bound cargo prefers to go straight through the intersection, and propose a model to explain this by a tug-of-war between motors on the lipid cargo that engage the actin tracks.https://doi.org/10.1038/ncomms15692
collection DOAJ
language English
format Article
sources DOAJ
author Andrew T. Lombardo
Shane R. Nelson
M. Yusuf Ali
Guy G. Kennedy
Kathleen M. Trybus
Sam Walcott
David M. Warshaw
spellingShingle Andrew T. Lombardo
Shane R. Nelson
M. Yusuf Ali
Guy G. Kennedy
Kathleen M. Trybus
Sam Walcott
David M. Warshaw
Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro
Nature Communications
author_facet Andrew T. Lombardo
Shane R. Nelson
M. Yusuf Ali
Guy G. Kennedy
Kathleen M. Trybus
Sam Walcott
David M. Warshaw
author_sort Andrew T. Lombardo
title Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro
title_short Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro
title_full Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro
title_fullStr Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro
title_full_unstemmed Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro
title_sort myosin va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-06-01
description Cellular cargo transported along actin filaments is faced with a directional choice at an intersection. Here the authors show that myosin Va-bound cargo prefers to go straight through the intersection, and propose a model to explain this by a tug-of-war between motors on the lipid cargo that engage the actin tracks.
url https://doi.org/10.1038/ncomms15692
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