Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro
Cellular cargo transported along actin filaments is faced with a directional choice at an intersection. Here the authors show that myosin Va-bound cargo prefers to go straight through the intersection, and propose a model to explain this by a tug-of-war between motors on the lipid cargo that engage...
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2017-06-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms15692 |
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doaj-9cbbb6d752f74a68bb343e25f12b6f662021-05-11T07:32:34ZengNature Publishing GroupNature Communications2041-17232017-06-01811910.1038/ncomms15692Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitroAndrew T. Lombardo0Shane R. Nelson1M. Yusuf Ali2Guy G. Kennedy3Kathleen M. Trybus4Sam Walcott5David M. Warshaw6Department of Molecular Physiology and Biophysics, University of VermontDepartment of Molecular Physiology and Biophysics, University of VermontDepartment of Molecular Physiology and Biophysics, University of VermontDepartment of Molecular Physiology and Biophysics, University of VermontDepartment of Molecular Physiology and Biophysics, University of VermontDepartment of Mathematics, University of CaliforniaDepartment of Molecular Physiology and Biophysics, University of VermontCellular cargo transported along actin filaments is faced with a directional choice at an intersection. Here the authors show that myosin Va-bound cargo prefers to go straight through the intersection, and propose a model to explain this by a tug-of-war between motors on the lipid cargo that engage the actin tracks.https://doi.org/10.1038/ncomms15692 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrew T. Lombardo Shane R. Nelson M. Yusuf Ali Guy G. Kennedy Kathleen M. Trybus Sam Walcott David M. Warshaw |
spellingShingle |
Andrew T. Lombardo Shane R. Nelson M. Yusuf Ali Guy G. Kennedy Kathleen M. Trybus Sam Walcott David M. Warshaw Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro Nature Communications |
author_facet |
Andrew T. Lombardo Shane R. Nelson M. Yusuf Ali Guy G. Kennedy Kathleen M. Trybus Sam Walcott David M. Warshaw |
author_sort |
Andrew T. Lombardo |
title |
Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro |
title_short |
Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro |
title_full |
Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro |
title_fullStr |
Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro |
title_full_unstemmed |
Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro |
title_sort |
myosin va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-06-01 |
description |
Cellular cargo transported along actin filaments is faced with a directional choice at an intersection. Here the authors show that myosin Va-bound cargo prefers to go straight through the intersection, and propose a model to explain this by a tug-of-war between motors on the lipid cargo that engage the actin tracks. |
url |
https://doi.org/10.1038/ncomms15692 |
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