Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives and Analogs Targeting the NLRP3 Inflammasome

Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives and Analogs Targeting the NLRP3 Inflammasome

A series of benzo[d]imidazole analogues of thiabenzole were synthesized and their antiinflammatory activities toward NLRP3 (nucleotide‐binding domain leucine‐rich repeat containing protein family，pyrin domain‐containing 3，also known as cryopyrin or NALP3) inflammasome were evaluated in vitro. Two le...

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Bibliographic Details
Main Authors: Liangkun Pan, Nan Hang, Chao Zhang, Yu Chen, Shuchun Li, Yang Sun, Zhongjun Li, Xiangbao Meng
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Molecules
Subjects:
benzimidazole
 NLRP3
 IL‐1β
 anti‐inflammatory
 drug discovery
Online Access:http://www.mdpi.com/1420-3049/22/2/213

Internet

http://www.mdpi.com/1420-3049/22/2/213

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