Altered microtubule structure, hemichannel localization and beating activity in cardiomyocytes expressing pathologic nuclear lamin A/C

Altered microtubule structure, hemichannel localization and beating activity in cardiomyocytes expressing pathologic nuclear lamin A/C

Given the clinical effect of laminopathies, understanding lamin mechanical properties will benefit the treatment of heart failure. Here we report a mechano-dynamic study of LMNA mutations in neonatal rat ventricular myocytes (NRVM) using single cell spectroscopy with Atomic Force Microscopy (AFM) an...

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Bibliographic Details
Main Authors: Daniele Borin, Brisa Peña, Suet Nee Chen, Carlin S. Long, Matthew R.G. Taylor, Luisa Mestroni, Orfeo Sbaizero
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Heliyon
Subjects:
Biological sciences
Cardiology
Biomechanics
Cytoskeleton
Mechanical property
Membrane
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020300207

Internet

http://www.sciencedirect.com/science/article/pii/S2405844020300207

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