Kinase Inhibitor Treatment of Patients with Advanced Cancer Results in High Tumor Drug Concentrations and in Specific Alterations of the Tumor Phosphoproteome

Kinase Inhibitor Treatment of Patients with Advanced Cancer Results in High Tumor Drug Concentrations and in Specific Alterations of the Tumor Phosphoproteome

Identification of predictive biomarkers for targeted therapies requires information on drug exposure at the target site as well as its effect on the signaling context of a tumor. To obtain more insight in the clinical mechanism of action of protein kinase inhibitors (PKIs), we studied tumor drug con...

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Bibliographic Details
Main Authors: Mariette Labots, Thang V. Pham, Richard J. Honeywell, Jaco C. Knol, Robin Beekhof, Richard de Goeij-de Haas, Henk Dekker, Maarten Neerincx, Sander R. Piersma, Johannes C. van der Mijn, Donald L. van der Peet, Martijn R. Meijerink, Godefridus J. Peters, Nicole C.T. van Grieken, Connie R. Jiménez, Henk M.W. Verheul
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
mass spectrometry
protein kinase inhibitor
phosphoproteomics
tumor drug concentration
cancer
tyrosine phosphorylation
Online Access:https://www.mdpi.com/2072-6694/12/2/330

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https://www.mdpi.com/2072-6694/12/2/330

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