Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification

Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification

Receptors for gonadotropin releasing hormone (GnRH) are highly expressed in various human cancers including breast, ovarian, endometrial, prostate and colorectal cancer. Ligands like human GnRH-I or the sea lamprey analogue GnRH-III represent a promising approach for the development of efficient dru...

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Bibliographic Details
Main Authors: Sabine Schuster, Beáta Biri-Kovács, Bálint Szeder, László Buday, János Gardi, Zsuzsanna Szabó, Gábor Halmos, Gábor Mező
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Pharmaceutics
Subjects:
targeted cancer therapy
drug delivery system
daunorubicin
gonadotropin releasing hormone III
peptide drug conjugates
oxime linkage
antitumor activity
cellular uptake
Online Access:https://www.mdpi.com/1999-4923/10/4/223

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https://www.mdpi.com/1999-4923/10/4/223

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