Vicagrel enhances aspirin-induced inhibition of both platelet aggregation and thrombus formation in rodents due to its decreased metabolic inactivation

Vicagrel enhances aspirin-induced inhibition of both platelet aggregation and thrombus formation in rodents due to its decreased metabolic inactivation

Both aspirin and vicagrel are effective antiplatelet drugs, with the potential for concomitant use as another dual-antiplatelet therapy for the prevention of recurrent thrombotic or ischemic events. Because they both are the substrates of carboxylesterase 2 (CES2), aspirin attenuated the metabolic a...

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Bibliographic Details
Main Authors: Yu-Meng Jia, Peng-Xin Ge, Huan Zhou, Jin-Zi Ji, Ting Tai, Tong-Tong Gu, Ting Zhu, Yi-Fei Li, Qiong-Yu Mi, Bei-Bei Huang, Hong-Guang Xie
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Aspirin
Carboxylesterase 2
Drug-drug interaction
Hydrolysis
Platelet aggregation
Vicagrel
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219308169

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http://www.sciencedirect.com/science/article/pii/S0753332219308169

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