Tropomyosin 2.1 collaborates with fibronectin to promote TGF-β1-induced contraction of human lung fibroblasts

Tropomyosin 2.1 collaborates with fibronectin to promote TGF-β1-induced contraction of human lung fibroblasts

Abstract Many lung diseases are characterized by fibrosis, leading to impaired tissue patency and reduced lung function. Development of fibrotic tissue depends on two-way interaction between the cells and the extra-cellular matrix (ECM). Concentration-dependent increased stiffening of the ECM is sen...

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Bibliographic Details
Main Authors: Peta Bradbury, Cassandra P. Nader, Aylin Cidem, Sandra Rutting, Dianne Sylvester, Patrick He, Maria C. Rezcallah, Geraldine M. O’Neill, Alaina J. Ammit
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Respiratory Research
Subjects:
Lung fibrosis
Tropomyosins
Fibronectin
Collagen contraction
Fibroblasts
Online Access:https://doi.org/10.1186/s12931-021-01730-y

Internet

https://doi.org/10.1186/s12931-021-01730-y

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