The Interaction of Klebsiella pneumoniae With Lipid Rafts-Associated Cholesterol Increases Macrophage-Mediated Phagocytosis Due to Down Regulation of the Capsule Polysaccharide

The Interaction of Klebsiella pneumoniae With Lipid Rafts-Associated Cholesterol Increases Macrophage-Mediated Phagocytosis Due to Down Regulation of the Capsule Polysaccharide

Klebsiella pneumoniae successfully colonizes host tissues by recognizing and interacting with cholesterol present on membrane-associated lipid rafts. In this study, we evaluated the role of cholesterol in the expression of capsule polysaccharide genes of K. pneumoniae and its implication in resistan...

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Bibliographic Details
Main Authors: Miguel A. Ares, Alejandro Sansabas, Diana Rodríguez-Valverde, Tania Siqueiros-Cendón, Quintín Rascón-Cruz, Roberto Rosales-Reyes, Ma. Dolores Jarillo-Quijada, María D. Alcántar-Curiel, María L. Cedillo, Javier Torres, Jorge A. Girón, Miguel A. De la Cruz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Klebsiella pneumoniae
cholesterol
capsule
phagocytosis
H-NS
RcsA
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00255/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2019.00255/full

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