Direct Testing for Allele-Specific Expression Differences Between Conditions

Direct Testing for Allele-Specific Expression Differences Between Conditions

Allelic imbalance (AI) indicates the presence of functional variation in cis regulatory regions. Detecting cis regulatory differences using AI is widespread, yet there is no formal statistical methodology that tests whether AI differs between conditions. Here, we present a novel model and formally t...

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Bibliographic Details
Main Authors: Luis León-Novelo, Alison R. Gerken, Rita M. Graze, Lauren M. McIntyre, Fabio Marroni
Format: Article
Language:English
Published: Oxford University Press 2018-02-01
Series:G3: Genes, Genomes, Genetics
Subjects:
robust regulation
allelic imbalance
allele-specific expression
gene regulatory networks
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.300139

Internet

http://g3journal.org/lookup/doi/10.1534/g3.117.300139

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