Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against <i>Leishmania donovani</i>

Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against <i>Leishmania donovani</i>

A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of <i>Leishmania donovani</i>. All 15 tested tetraoxanes displayed activity, with IC<sub>50</sub> values ranging from 2 to 45 &#181;m. The most...

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Bibliographic Details
Main Authors: Lília I. L. Cabral, Sébastien Pomel, Sandrine Cojean, Patrícia S. M. Amado, Philippe M. Loiseau, Maria L. S. Cristiano
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
leishmaniasis
antileishmanial chemotherapy
peroxide-derived antimalarials
tetraoxanes
antimalarials re-purposing
Online Access:https://www.mdpi.com/1420-3049/25/3/465

Internet

https://www.mdpi.com/1420-3049/25/3/465

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