The Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune Diseases

The Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune Diseases

The Kv1.3 channel-acting scorpion toxins usually adopt the conserved anti-parallel β-sheet domain as the binding interface, but it remains challenging to discover some highly selective Kv1.3 channel-acting toxins. In this work, we investigated the pharmacological profile of the Kv1.3 channel-acting...

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Bibliographic Details
Main Authors: Fang Ye, Youtian Hu, Weiwei Yu, Zili Xie, Jun Hu, Zhijian Cao, Wenxin Li, Yingliang Wu
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Toxins
Subjects:
Kv1.3 channel
BmKTX
scorpion toxin
BmKTX-D33H
ion channel selectivity
autoimmune diseases
Online Access:http://www.mdpi.com/2072-6651/8/4/115

Internet

http://www.mdpi.com/2072-6651/8/4/115

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