Sirt1 ameliorates chronic mild unpredictable stress-induced depression-like behaviors in mice by promoting hippocampal microglia M2 polarization

Sirt1 ameliorates chronic mild unpredictable stress-induced depression-like behaviors in mice by promoting hippocampal microglia M2 polarization

Objective To explore the effect of silent mating-type information regulation 2 homolog 1 (Sirt1) on depression-like behaviors in mice and the underlying molecular mechanism. Methods Forty 8-week-old male C57BL/6 mice were subjected to chronic mild unpredictable stress (CUMS) to establish models of d...

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Bibliographic Details
Main Authors: WANG Yue, WAN Tengfei, DUAN Chunme, WANG Li, CHEN Xiaoyan
Format: Article
Language:zho
Published: Editorial Office of Journal of Third Military Medical University 2019-07-01
Series:Di-san junyi daxue xuebao
Subjects:
depression
silent mating-type information regulation 2 homolog 1
microglia
gsk3β/pten
Online Access:http://aammt.tmmu.edu.cn/Upload/rhtml/201901077.htm

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http://aammt.tmmu.edu.cn/Upload/rhtml/201901077.htm

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