HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia

HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia

Histone deacetylase 8 (HDAC8), a class I HDAC that modifies non-histone proteins such as p53, is highly expressed in different hematological neoplasms including a subtype of acute myeloid leukemia (AML) bearing inversion of chromosome 16 [inv(16)]. To investigate HDAC8 contribution to hematopoietic...

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Bibliographic Details
Main Authors: Marco Spreafico, Alicja M. Gruszka, Debora Valli, Mara Mazzola, Gianluca Deflorian, Arianna Quintè, Maria Grazia Totaro, Cristina Battaglia, Myriam Alcalay, Anna Marozzi, Anna Pistocchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HDAC8
AML
PCI-34051
zebrafish
p53
WNT
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00844/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00844/full

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