HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia

HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia

Histone deacetylase 8 (HDAC8), a class I HDAC that modifies non-histone proteins such as p53, is highly expressed in different hematological neoplasms including a subtype of acute myeloid leukemia (AML) bearing inversion of chromosome 16 [inv(16)]. To investigate HDAC8 contribution to hematopoietic...

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Bibliographic Details
Main Authors:	Marco Spreafico, Alicja M. Gruszka, Debora Valli, Mara Mazzola, Gianluca Deflorian, Arianna Quintè, Maria Grazia Totaro, Cristina Battaglia, Myriam Alcalay, Anna Marozzi, Anna Pistocchi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-09-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	HDAC8 AML PCI-34051 zebrafish p53 WNT
Online Access:	https://www.frontiersin.org/article/10.3389/fcell.2020.00844/full

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