Insights Into Dynamics of Inhibitor and Ubiquitin-Like Protein Binding in SARS-CoV-2 Papain-Like Protease

Insights Into Dynamics of Inhibitor and Ubiquitin-Like Protein Binding in SARS-CoV-2 Papain-Like Protease

Covid-19 is caused by a novel form of coronavirus for which there are currently no vaccines or anti-viral drugs. This virus, termed SARS-CoV-2 (CoV2), contains Papain-like protease (PLpro) involved in viral replication and immune response evasion. Drugs targeting this protease therefore have great p...

Full description

Bibliographic Details
Main Authors: Yuliana K. Bosken, Timothy Cholko, Yuan-Chao Lou, Kuen-Phon Wu, Chia-en A. Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
structure-based drug design
computational biology and chemistry
non-covalent molecular recognition
conformational change
protein entropy
biophysics
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00174/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.00174/full

Similar Items