Allele Drop Out Conferred by a Frequent CYP2D6 Genetic Variation For Commonly Used CYP2D6*3 Genotyping Assays

Allele Drop Out Conferred by a Frequent CYP2D6 Genetic Variation For Commonly Used CYP2D6*3 Genotyping Assays

Background/Aim: Accurate genotyping of CYP2D6 is challenging due to its inherent genetic variation, copy number variation (duplications and deletions) and hybrid formation with highly homologous pseudogenes. Because a relatively high percentage (∼25%) of clinically prescribed drugs are substrates fo...

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Bibliographic Details
Main Authors: Giada Scantamburlo, Konstantina Tziolia, Michaela Zopf, Emanuele Bernardinelli, Selma M. Soyal, Davide Antonio Civello, Simone Vanoni, Silvia Dossena, Wolfgang Patsch, George P. Patrinos, Markus Paulmichl, Charity Nofziger
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
Pharmacogenomics
Pharmacogenetics
Precision medicine
Pyrosequencing
Online Access:https://www.karger.com/Article/FullText/484380

Internet

https://www.karger.com/Article/FullText/484380

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