Allele Drop Out Conferred by a Frequent CYP2D6 Genetic Variation For Commonly Used CYP2D6*3 Genotyping Assays
Background/Aim: Accurate genotyping of CYP2D6 is challenging due to its inherent genetic variation, copy number variation (duplications and deletions) and hybrid formation with highly homologous pseudogenes. Because a relatively high percentage (∼25%) of clinically prescribed drugs are substrates fo...
Main Authors: | Giada Scantamburlo, Konstantina Tziolia, Michaela Zopf, Emanuele Bernardinelli, Selma M. Soyal, Davide Antonio Civello, Simone Vanoni, Silvia Dossena, Wolfgang Patsch, George P. Patrinos, Markus Paulmichl, Charity Nofziger |
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Format: | Article |
Language: | English |
Published: |
Cell Physiol Biochem Press GmbH & Co KG
2017-10-01
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Series: | Cellular Physiology and Biochemistry |
Subjects: | |
Online Access: | https://www.karger.com/Article/FullText/484380 |
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