Amphiphilic Polymeric Micelles Based on Deoxycholic Acid and Folic Acid Modified Chitosan for the Delivery of Paclitaxel

Amphiphilic Polymeric Micelles Based on Deoxycholic Acid and Folic Acid Modified Chitosan for the Delivery of Paclitaxel

The present investigation aimed to develop a tumor-targeting drug delivery system for paclitaxel (PTX). The hydrophobic deoxycholic acid (DA) and active targeting ligand folic acid (FA) were used to modify water-soluble chitosan (CS). As an amphiphilic polymer, the conjugate FA-CS-DA was synthesized...

Full description

Bibliographic Details
Main Authors: Liang Li, Na Liang, Danfeng Wang, Pengfei Yan, Yoshiaki Kawashima, Fude Cui, Shaoping Sun
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
chitosan
deoxycholic acid
folic acid
amphiphilic polymer
micelles
paclitaxel
Online Access:http://www.mdpi.com/1422-0067/19/10/3132

Internet

http://www.mdpi.com/1422-0067/19/10/3132

Similar Items