Subcutaneous Immunization of <i>Leishmania HSP70-II</i> Null Mutant Line Reduces the Severity of the Experimental Visceral Leishmaniasis in BALB/c Mice

Subcutaneous Immunization of <i>Leishmania HSP70-II</i> Null Mutant Line Reduces the Severity of the Experimental Visceral Leishmaniasis in BALB/c Mice

<i>Leishmania infantum</i> parasites cause a severe form of visceral leishmaniasis in human and viscerocutaneous leishmaniasis in dogs. Recently, we reported that immunization with an attenuated <i>L. infantum</i> cell line, lacking the <i>hsp70-II</i> gene, prote...

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Bibliographic Details
Main Authors: José Carlos Solana, Laura Ramírez, Emma CL Cook, Elena Hernández-García, Silvia Sacristán, M. Elena Martín, Víctor Manuel González, Rosa María Reguera, Rafael Balaña-Fouce, Manuel Fresno, José María Requena, Salvador Iborra, Manuel Soto
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Vaccines
Subjects:
visceral leishmaniasis
mice
attenuated parasites
vaccine
ifn-γ
t-cells
Online Access:https://www.mdpi.com/2076-393X/8/1/141

Internet

https://www.mdpi.com/2076-393X/8/1/141

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