Employing a Mechanistic Model for the Mapk Pathway to Examine the Impact of Cellular all or None Behavior on Overall Tissue Response

The mitogen activated protein kinase (MAPK) cascade is a three-tiered phosphorylation cascade that is ubiquitously expressed among eukaryotic cells. Its primary function is to propagate signals from cell surface receptors to various cytosolic and nuclear targets. Recent studies have demonstrated tha...

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Bibliographic Details
Main Authors: Nicholas S. Luke, Michael J. DeVito, Christopher J. Portier, Hisham A. El-Masri
Format: Article
Language:English
Published: SAGE Publishing 2010-07-01
Series:Dose-Response
Online Access:https://doi.org/10.2203/dose-response.09-017.Luke