An Msh3 ATPase domain mutation has no effect on MMR function
Abstract Objective To demonstrate that the Msh3 ATPase domain is required for DNA mismatch repair and tumor suppression in a murine model. Results The DNA mismatch repair proteins are members of the ABC family of ATPases. ATP binding and hydrolysis regulates their mismatch repair function. In the cu...
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| Format: | Article |
| Language: | English |
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BMC
2017-11-01
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| Series: | BMC Research Notes |
| Online Access: | http://link.springer.com/article/10.1186/s13104-017-2939-4 |