Acute epileptiform activity induced by gabazine involves proteasomal rather than lysosomal degradation of KCa2.2 channels

Voltage-independent, Ca2+-activated K+ channels (KCa2.2, previously named SK2) are typically activated during a train of action potentials, and hence, are powerful regulators of cellular excitability by generating an afterhyperpolarizing potential (AHP) following prolonged excitation. In the acute i...

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Bibliographic Details
Main Authors: Steffen Müller, Xiati Guli, Judith Hey, Anne Einsle, Daniela Pfanz, Victor Sudmann, Timo Kirschstein, Rüdiger Köhling
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Neurobiology of Disease
Subjects:
PKA
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300056