On-chip crystallization for serial crystallography experiments and on-chip ligand-binding studies

On-chip crystallization for serial crystallography experiments and on-chip ligand-binding studies

Efficient and reliable sample delivery has remained one of the bottlenecks for serial crystallography experiments. Compared with other methods, fixed-target sample delivery offers the advantage of significantly reduced sample consumption and shorter data collection times owing to higher hit rates. H...

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Bibliographic Details
Main Authors: Julia Lieske, Maximilian Cerv, Stefan Kreida, Dana Komadina, Janine Fischer, Miriam Barthelmess, Pontus Fischer, Tim Pakendorf, Oleksandr Yefanov, Valerio Mariani, Thomas Seine, Breyan H. Ross, Eva Crosas, Olga Lorbeer, Anja Burkhardt, Thomas J. Lane, Sebastian Guenther, Julian Bergtholdt, Silvan Schoen, Susanna Törnroth-Horsefield, Henry N. Chapman, Alke Meents
Format: Article
Language:English
Published: International Union of Crystallography 2019-07-01
Series:IUCrJ
Subjects:
serial crystallography
silicon chip
fixed-target crystallography
in-situ diffraction
vapor diffusion
ligand binding
ligand soaking
drug discovery
protein structure
X-ray crystallography
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252519007395

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http://scripts.iucr.org/cgi-bin/paper?S2052252519007395

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