Lysosomal cholesterol derived from mildly oxidized low density lipoprotein is resistant to efflux
In atherosclerotic lesions, macrophages store lipid in cytoplasmic inclusions and lysosomes. Regression studies show that lysosomal lipid is not as easily cleared as cytoplasmic inclusion lipid. Macrophages enriched with mildly oxidized low density lipoprotein (oxLDL) accumulate cholesteryl ester (C...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2001-03-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520316540 |