IL-22/IL-22R1 signaling regulates the pathophysiology of chronic rhinosinusitis with nasal polyps via alteration of MUC1 expression

IL-22/IL-22R1 signaling regulates the pathophysiology of chronic rhinosinusitis with nasal polyps via alteration of MUC1 expression

Background: IL-22 is an IL-10-family cytokine that regulates chronic inflammation. We investigated the role of IL-22 and its receptor, IL-22R1, in the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP). Methods: IL-22 and IL-22R1 protein and mRNA expression in NP and in uncinate ti...

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Bibliographic Details
Main Authors: Yasuyuki Noyama, Mitsuhiro Okano, Tazuko Fujiwara, Shin Kariya, Takaya Higaki, Takenori Haruna, Sei-ichiro Makihara, Kengo Kanai, Takahisa Koyama, Masami Taniguchi, Jun-ichi Ishitoya, Akira Kanda, Yoshiki Kobayashi, Mikiya Asako, Koichi Tomoda, Kazunori Nishizaki
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Allergology International
Subjects:
Chronic rhinosinusitis with nasal polyps
Exotoxins
IL-22
MUC1
Staphylococcus aureus
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893016300582

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http://www.sciencedirect.com/science/article/pii/S1323893016300582

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